DTI tools

DTI tools for assessment of the visual pathways

Lesions affecting the visual pathways in the human brain are common and may cause reduced visual acuity or visual field defects, either directly or as a result of surgery. These pathways can be visualised using tractography. The procedure is based on a combination of a magnetic resonance imaging technique known as diffusion tensor imaging (DTI) and computer-based image analysis.

MedTech West is developing novel DTI-based software tools for visualising and quantitatively characterising the visual pathways. The aim is to provide a suite of tools for use in neurosurgical planning.

Our approach

Our approach involves:

  1. Developing a tractography method that yields the most anatomically accurate demonstration of the visual pathways. This is assessed by comparing the tractography from healthy controls to pathways in a histological atlas that have been transferred to a standard magnetic resonance image of the brain (MNI brain atlas).
  2. Developing/evaluating DTI and tractography features that quantitatively characterise the pathways.
  3. Developing/evaluating classifiers, based on the features in (ii), for detecting early signs of injury to the visual pathways, distinguishing between compression and infiltration of the pathways by a tumour, and predicting visual function.

The resulting DTI tools offer the possibility for improved neurosurgical planning with correspondingly better patient outcomes.

Research team

MedTech West partner

Dr. Andrew Mehnert, Department of Signals and Systems, Chalmers University of Technology.

Technical research partner

Prof. Irene Gu, Department of Signals and Systems, Chalmers University of Technology.

Mohammed Alipoor, PhD Student, Department of Signals and Systems, Chalmers University of Technology.

Clinical partner

Dr. Daniel Nilsson, MD, Institute of Neuroscience and Physiology, Clinical Neurophysiology, Sahlgrenska University Hospital.

Dr Ylva Lilja, MD, ENT Clinic, Sahlgrenska University Hospital.

Contact

For more information on this project, contact Henrik Mindedal at henrik.mindedal@medtechwest.se