Date(s) - 11/04/2018
11:30 - 13:00
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Although highly desired, there are currently no non-invasive methods to collect samples from distal airways for robust biomarker analysis.
Researchers from the Breath Analyses Research-group at the Sahlgrenska University Hospital have developed a simple non-invasive method to sample biological material from small airways. By asking the patient to breath into the PExA instrument, small droplet particles that are formed from the lining fluid when small airways close and re-open, can be measured and collected. It has been shown that the molecular makeup of this sample matrix is similar to broncho-alveolar lavage fluid. Interesting data from small pilot studies show an aberrant molecular composition of PEx samples from subjects with, asthma, chronic obstructive lung-disease, gastro-esophageal reflux and also from transplanted patients with chronic rejection. Because PEx sample originate from a site close to where the pathological processes take place, there are reasons to believe that PEx-based biomarkers have the potential to detect disease at an earlier stage and with higher specificity than what may be expected from blood-based biomarkers. In prospect the method carries potential to become a valuable tool in basic research as well as in clinical practice.
In this lunchseminar, Anna-Carin Olin and Jörgen Östling will describe the PExA method, current research and the future plan for the method and the PExA company.
When? 11:30-13:00 on 11 April, 2018
Where? Hjärtats aula, Vita stråket 12, Sahlgrenska University Hospital
Participants registered before 15:30 on 6 April will be served a light lunch. VERY WELCOME!
Anna-Carin Olin is senior consultant and professor in Occupational and Environmental Medicine at Sahlgrenska University Hospital. She made her PhD at Gothenburg University in 2002 on Exhaled Nitric Oxide, and has since focused on development and validation of non-invasive methods to assess small airways. She is heading the research group “Breath Analyses” at the Dept for Societal Medicine and Public Health. The research is focused on effects on exposure to workplace and outdoor pollutants and effects on small airways, including effects on the lining fluid of small airways, using the PExA method.
Jörgen Östling has over 20 years of experience from pharma industry doing proteomics, biomarker discovery and bioinformatics, where of the last 6 years within the respiratory iMED biotech unit at AstraZeneca. In collboration with Anna-Carin’s group, he has explored the possibility to analyse the protein composition of PEx samples. Results from these pilot experiments are rather encouraging and he recently joined the PExA company, where he among other things support customers in their efforts exploring the molecular content of PEx samples.
PExA AB develops and markets a research instrument with associated products and services for lung researchers for simple and non-invasive sampling, for the purpose of studying respiratory diseases such as asthma and chronic obstructive pulmonary disease, COPD. Sampling with PExA can be used to detect lung diseases at an early stage. The sample may be similar to a “small airway test”. The aim is to facilitate the development of reliable and more individualized diagnosis, monitoring and treatment of respiratory diseases. The original idea and research behind the method comes from the Department of Occupational and Environmental Medicine at the Sahlgrenska Academy. The commercial business started in 2010 with the support of GU Venture’s incubator and the company is founded by inventors, key employees, business angels and GU Ventures.
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