MedTech West lunch seminar: FLU-ID – Bioassays for fast and sensitive detection of pandemic influenza using ultra-sensitive magnetometry and wiggling nanomagnets
At this MedTech West lunchseminar, Dag Winkler, professor at the Department of Microtechnology and Nanoscience, Quantum Device Physics Laboratory, Chalmers University of Technology, and doctoral student Sobhan Sepehri will give us a review of the project SSF FLU-ID.
Pandemic influenza poses a threat unlike any other public health emergency or natural disaster, especially in terms of its complexity, distribution and ability to devastate society on a global scale. WHO has estimated that during each annual influenza epidemics 5-15% of the population is affected, with an associated 3-5 million severe cases and 250.000-500.000 deaths worldwide. Children have the highest influenza attack rates with annual incidence rates of up to 30%.
In the USA, influenza accounts for US$ 1-3 billion in direct medical costs each year; indirect costs, including lost earnings due to illness and lost future earnings due to death, are much higher, in the range US$10-15 billion per year. The figures for Europe are similar. In order to limit the health related, as well as economic, consequences, rapid, sensitive, and specific diagnostic assays are important. Established testing procedures take from 3-10 days (viral cell cultures) to <30 min (immunechromato-graphic lateral flow and membrane-based immunoassays). However, all currently recommended tests are performed in dedicated bioanalytical laboratories. Furthermore, assay instrumentation is typically large and rather expensive, and not available at the point of care or in smaller emergency wards, so the actual turn-around-time required is usually hours or days. Thus, a reliable assay with a short turn-around-time for detecting influenza-infections in respiratory samples is highly desirable. With the aim to develop a solution that shortens the total time for the diagnostic test to less than 60 minutes, while achieving a target sensitivity of 600 molecules per milliliter of sample. To solve this problem a consortium of groups in various fields has been formed. The methods and instruments developed in the FLU-ID project focus on influenza, but are generic and not limited to this specific disease. Many relevant microorganisms, for example staphylococci (MRSA), noro- and sapoviruses (acute gastroenteritis), parasitic protozoa (malaria) and zoonotic pathogens (~60% of all pathogens infecting humans) require a similar diagnostic approach.
The FLU-ID project is supported by the Swedish Foundation for Strategic Research (SSF) within the Medical Bioengineering program.
CLICK HERE TO REGISTER before 13.00 pm. on 10 Nov. 2016 to get a lunch sandwich after the seminar.
When? Monday 14 November 2016 at 11.30 – 12.30 (13.00 incl. lunch)
Where? Kammaren, Vita stråket 12, Sahlgrenska University Hospital