MedTech West seminar – Focal MEG: Developing a new neuroimaging system from the ground up

Magnetoencephalography (MEG) is a method of neuroimaging that records the magnetic fields generated by electrical activity in the brain. Clinically, MEG is used for localization of spike activity generated by epileptic foci as well as in pre-surgical mapping of eloquent brain regions. We at MedTech West are working to develop an advanced MEG system—“Focal MEG”—that enables, e.g., improved spatial resolution and the ability to detect more complicated sources of brain activity in comparison to the state-of-the-art. The system is based on high-Tc SQUIDs (high critical-temperature superconducting quantum interference devices) that are a new class of sensor technology in the field. We have demonstrated both the theoretical benefit of making a paradigm shift to high-Tc sensors in MEG (1) as well as proof-of-principle 2-channel recordings of spontaneous brain activity (2). Present activities include benchmarking our sensors against conventional ones in a state-of-the-art MEG system at the newly-inaugurated Swedish NatMEG facility and development of our own MEG system with more high-Tc SQUID channels.

In this seminar, Justin will present a bit of the history of, and motivation for, using MEG in experimental neuroscience—as well as clinical—settings. He will compare and contrast MEG with other popular neuroimaging methods. After a brief explanation of the physical and physiological bases for MEG as a neuroimaging technique, Justin will present the motivation for development of Focal MEG. The aim is to construct a full-head MEG system based on high-Tc SQUID sensors that maximizes the benefits they provide while accounting for their limitations. He will conclude by presenting proof-of-principle spontaneous brain activity recordings with our 2-channel MEG system, ongoing work, and future research and development activities towards a clinically-useful Focal MEG system.

The seminar will be presented by Justin F. Schneiderman, Associate Professor at MedTech West and the Sahlgrenska Academy/University of Gothenburg Institute of Neuroscience and Physiology.

Date: February 6, 2014
Time: 11:30-12:15 (-13 incl lunch)
Room: Förmaket, Vita Stråket 12, Sahlgrenska University Hospital

Register by sending an email to seminars@medtechwest.se. Please write “Seminar February 6” in the subject line. Last day for registration is February 3.

 

(1) J. F. Schneiderman.  Journal of Neuroscience Methods 222 (2014): 42– 46
(2) F. Öisjöen, J. F. Schneiderman, G. A. Figueras, M. L. Chukharkin, A. Kalabukhov et al. Appl. Phys. Lett. 100, 132601 (2012)